Durability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a


The SARS-CoV-2 omicron (B.1.1.529) variant was originally identified in Botswana and South Africa in November, 2021. Compared to the original SARS-CoV-2 strain (Wuhan-Hu-1), omicron (including BA lineages of B.1.1.529) has more than 30 mutations in its spike (S) protein. Many of these mutations are in the receptor-binding domain and have been shown to correspond with a high degree of transmissibility and neutralising antibody escape.


  • Viana R
  • Moyo S
  • Amoako DG
  • et al.
Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa.